Thermo Fisher Scientific MASTL Polyclonal Antibody
MASTL 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체. 인간 및 마우스 시료에서 사용 가능하며, Western blot에 적합. 액상 형태로 1 mg/mL 농도, 항원 친화 크로마토그래피로 정제됨. 세포 주기 및 암 연구용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from C-terminal of human MASTL |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635323 |
Product Specific Information
This antibody detects endogenous levels of total MASTL protein.
Target Information
MASTL (microtubule associated serine/threonine kinase-like) belongs to the MAST family, AGC Ser/Thr protein kinase group.
MASTL promotes mitotic progression and cell cycle reentry after DNA damage. Loss of MASTL leads to defects in chromosome condensation, separation, and other aspects of mitotic progression, mainly mediated by inhibition of PP2A/B55 delta.
Overexpression of MASTL is correlated with cancer progression, poor patient survival, and tumor recurrence in various cancers.
Mutations at this locus have been associated with autosomal dominant thrombocytopenia (thrombocytopenia-2).
Alternatively spliced transcript variants have been described for this locus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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