Thermo Fisher Scientific Amyloid Precursor Protein Polyclonal Antibody
Thermo Fisher Scientific의 Amyloid Precursor Protein Polyclonal Antibody는 인간, 마우스, 랫트에 반응하는 래빗 폴리클로날 항체입니다. Western blot 및 IHC에 사용 가능하며, APP 및 C99 fragment를 인식합니다. 알츠하이머 연구 등 베타 아밀로이드 관련 연구에 적합합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 2 publications |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | View publication |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 737–751 of human APP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2056589 |
Product Specific Information
PA1-84165 recognizes both intact APP and the C99 fragment generated by Beta-secretase.
The sequence recognized by this antibody corresponds to amino acids 85–99 of the C99 fragment.
Heat-mediated antigen retrieval is recommended for staining of paraffin sections.
Target Information
Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals with Alzheimer’s disease.
Abeta peptide (40–43 amino acids) is generated from beta-amyloid precursor protein (beta APP) through a two-step cleavage process involving beta-secretase (BACE) and gamma-secretase.
Gamma-secretase is a multi-subunit complex containing presenilin-1 and presenilin-2, and associated glycoprotein nicastrin modulates Abeta production.
Abeta forms extracellular filamentous deposits in amyloid cores, neuritic plaques, and neurofibrillary tangles.
Beta amyloid deposits are also found in Lewy body dementia, Down’s syndrome, Dutch-type amyloidosis, cerebral amyloid angiopathy, and Guam Parkinson-Dementia complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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