Thermo Fisher Scientific IRF3 Polyclonal Antibody
IRF3 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태입니다. 인간 단백질에 반응하며, 4°C에서 보관 권장됩니다.
- 카탈로그번호
- A300426A
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (IHC) | 1:200–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 100 and 150 of human Interferon Regulatory Factor 3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
IRF3 (Interferon Regulatory Factor 3) is a key transcriptional regulator of type I interferon (IFN)-dependent immune responses. It plays a critical role in the innate immune response against DNA and RNA viruses by regulating the transcription of type I IFN genes (IFN-α and IFN-β) and IFN-stimulated genes (ISG) through binding to interferon-stimulated response elements (ISRE).
IRF3 is inactive in the cytoplasm of uninfected cells and becomes activated upon phosphorylation by IKBKE and TBK1 kinases following viral infection or toll-like receptor signaling. This activation induces dimerization and nuclear localization, forming the dsRNA-activated factor 1 (DRAF1) complex that activates transcription of type I IFN and ISG genes.
Mutations in IRF3 can lead to acute, infection-induced, herpes-specific encephalopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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