Thermo Fisher Scientific VANGL1 Polyclonal Antibody
VANGL1 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human 및 Mouse 시료에 반응합니다. Western blot과 Immunocytochemistry에 적합하며, 1 mg/mL 농도의 액상 형태로 제공됩니다. Affinity chromatography로 정제되어 높은 특이성과 재현성을 보장합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human VANGL1 (Accession Q8TAA9), corresponding to amino acid residues R352–A402 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851386 |
Product Specific Information
This antibody detects endogenous levels of total VANGL1.
Target Information
Vang-like 1 protein is a human homologue of Drosophila Van Gogh/Strabismus. The Vang-like 1 gene consists of at least seven exons and encodes a protein with four transmembrane domains and a C-terminal Ser/Thr-X-Val motif.
Studies have shown that VANGL1 expression is significantly upregulated in gastric cancer (MKN28, MKN74) and pancreatic cancer cell lines (BxPC-3, PSN-1, Hs766T).
The protein may act as an effector mediating intestinal trefoil factor (ITF) healing responses and serves as a diagnostic marker for hepatocellular carcinoma.
It is also implicated in neural tube defects (NTD). The human Vang-like 1 gene maps to chromosome 1p11–p13.1.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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