Thermo Fisher Scientific MIP-3 beta Polyclonal Antibody
인간 CCL19 단백질을 인식하는 Rabbit IgG 폴리클로날 항체로, IHC(P)에서 1:200~1:500 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol 버퍼에 보존. 면역세포 이동 및 활성화 연구에 적합.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CCL19. Recombinant protein control fragment (Product #RP-107597). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2791917 |
Product Specific Information
Immunogen sequence:
LLIKDGCRVP AVVFTTLRGR QLCAPPDQPW VERIIQRLQR TSAKMKRRSS
Target Information
CCL19, also known as MIP-3 beta (Macrophage Inflammatory Protein 3 beta), is a member of the CC-subfamily of chemokines. It is closely related to CCL21, sharing 32% amino acid sequence homology. CCL19 and CCL21 are mainly expressed by stromal cells in T cell-rich zones of lymph nodes and play a crucial role in homeostatic trafficking of naive T cells and activated dendritic cells into secondary lymphoid organs. They also contribute to T cell priming, activation, and lymphocyte recruitment to inflamed tissues. Both signal through the G protein-coupled receptor CCR7, expressed on T cells and mature dendritic cells. While both bind CCR7 with similar affinity, only CCL19 induces receptor desensitization and internalization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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