Thermo Fisher Scientific KIR2D Polyclonal Antibody
KIR2D 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, Western blot에 최적화됨. Human 시료에 반응하며 Protein A 및 항원 친화 크로마토그래피로 정제됨. PBS buffer에 0.09% sodium azide 함유, 4°C 단기 보관 및 -20°C 장기 보관 권장.
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Applications
- Western Blot (WB): 1:1,000 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 151–180 of human KIR2DS1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2900841 |
Target Information
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous, located on chromosome 19q13.4 within the leukocyte receptor complex (LRC).
KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by the length of their cytoplasmic domain (L or S).
- Long cytoplasmic domain (L): Transduces inhibitory signals via immune tyrosine-based inhibitory motifs (ITIM).
- Short cytoplasmic domain (S): Lacks ITIM and associates with TYRO protein tyrosine kinase binding protein to transduce activating signals.
Ligands for several KIR proteins include subsets of HLA class I molecules, suggesting their key role in immune regulation.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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배송 정보
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