Thermo Fisher Scientific AKR1C3 Polyclonal Antibody
AKR1C3 단백질을 인식하는 Thermo Fisher Scientific의 산양 유래 폴리클로날 항체. Western blot 및 IHC(P) 실험에 적합하며, 고순도의 액상 형태로 제공. 인체 유래 단백질 반응성, 안정한 보관 및 운송 조건 제공.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.01–0.1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (CFASHPNYPYSDEY) corresponding to the C-terminus amino acids of AKR1C3 (aa 311–323). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10985133 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.
Target Information
AKR1C3 is a member of the aldo/keto reductase superfamily, which includes more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. They display overlapping but distinct substrate specificity.
This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2, and phenanthrenequinone (PQ), as well as the oxidation of 9-alpha,11-beta-PGF2 to PGD2. It may play an important role in allergic disease pathogenesis such as asthma and may also be involved in cell growth and differentiation. The gene shares high sequence identity with three other gene members and is clustered with them at chromosome 10p15–p14.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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