Thermo Fisher Scientific DCP1A Polyclonal Antibody
Thermo Fisher Scientific의 DCP1A Polyclonal Antibody는 인간 DCP1A 단백질의 C-말단 펩타이드 서열을 면역원으로 한 염소 유래 항체입니다. Western blot에 최적화되어 있으며, 마우스 및 랫트에서도 반응이 예측됩니다. 0.5 mg/mL 농도의 액상 형태로 제공되며, -20°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1–3 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (QVLTKNKDNHN) corresponding to the C-terminus amino acids of DCP1A (aa 571–582) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10986742 |
Product Specific Information
- This antibody is predicted to react with mouse and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 1:16,000.
Target Information
Signal transduction of TGF-beta superfamily members is regulated by Smad proteins. Smads influence specific gene transcription by relaying signals from the cell membrane to the nucleus. Smad4 plays an essential role in TGF-beta-induced transcriptional activation wherein phosphorylated receptor-associated Smads associate with Smad4.
SMIF (Smad4-interacting protein) and Smad4 complex with TGF-beta and BMP4. An increase in Smad4 concentration enhances the translocation of this complex to the nucleus. SMIF and Smad4 interact directly through an EVH1/WH1 domain on SMIF and a proline-rich activation domain on Smad4. Smad4 is essential to nuclear translocation of SMIF, as deletion of the Smad4-interacting domain (located in the N-terminal 100 amino acids) of SMIF eliminates TGF-beta-induced nuclear translocation of SMIF.
The human SMIF gene is ubiquitously expressed and encodes a protein with a relative molecular mass of approximately 70 kDa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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