Thermo Fisher Scientific Lamin-A Polyclonal Antibody
Rabbit polyclonal antibody targeting human Lamin A (residues 400–450). Suitable for WB, IHC, ICC/IF, and IP applications. Recommended fixation and retrieval methods provided. Predicted cross-reactivity with rat and pig. Supplied as liquid, 0.2 mg/mL, s...
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:500 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 400 and 450 of human Lamin A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Notes:
- For ICC: Formaldehyde fixation and permeabilization with Triton-X 100 are recommended.
- For IHC: Epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
- Based on 100% sequence identity, this antibody is predicted to react with Rat and Pig.
Target Information
Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic side of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished: A-type lamins and B-type lamins.
A-type lamins include lamin A, lamin C, and lamin Adel 10, which arise from the same gene by alternative splicing. B-type lamins (lamin B1 and lamin B2) are encoded by distinct genes.
Mutations in A-type lamins are associated with several rare but dominant genetic disorders, including:
- Emery-Dreifuss muscular dystrophy
- Dilated cardiomyopathy with conduction-system disease
- Dunnigan-type familial partial lipodystrophy
Expression of A-type lamins correlates with cell differentiation. Their specific interaction with chromatin suggests a potential role in regulating differential gene expression.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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