Thermo Fisher Scientific TCIRG1 Polyclonal Antibody

Product Specifications

Product Specific Information

Immunogen sequence:
RPADRQEENK AGLLDLPDAS VNGWSSDEEK AGGLDDEEEA ELVPSEVLMH QAIHTI

Highest antigen sequence identity to the following orthologs:

• Mouse: 62%
• Rat: 62%

Target Information

The T-cell immune regulator 1 (TCIRG1) is the a3 subunit of the vacuolar-type proton transporting ATPase (V-ATPase), a proton pump in late endosomes and lysosomes that functions in the luminal acidification of these organelles.
Genetic defects in the gene encoding this protein are responsible for a severe form of autosomal recessive osteopetrosis, a condition that leads to increased bone density, decreased bone strength, and inflammation in bone tissues.
TCIRG1 is also required for the normal secretion of insulin and the bacteria-killing function of macrophages.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.