Thermo Fisher Scientific TCIRG1 Polyclonal Antibody
Rabbit 유래의 TCIRG1 폴리클로날 항체로 인간 TCIRG1 단백질을 인식합니다. V-ATPase 복합체 연구에 적합하며, 액상 형태로 제공됩니다. 단기 보관은 4°C, 장기 보관은 -20°C에서 권장됩니다. 연구용으로만 사용 가능합니다.
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Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human TCIRG1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2648321 |
Product Specific Information
Immunogen sequence:
RPADRQEENK AGLLDLPDAS VNGWSSDEEK AGGLDDEEEA ELVPSEVLMH QAIHTI
Highest antigen sequence identity to the following orthologs:
- Mouse: 62%
- Rat: 62%
Target Information
The T-cell immune regulator 1 (TCIRG1) is the a3 subunit of the vacuolar-type proton transporting ATPase (V-ATPase), a proton pump in late endosomes and lysosomes that functions in the luminal acidification of these organelles.
Genetic defects in the gene encoding this protein are responsible for a severe form of autosomal recessive osteopetrosis, a condition that leads to increased bone density, decreased bone strength, and inflammation in bone tissues.
TCIRG1 is also required for the normal secretion of insulin and the bacteria-killing function of macrophages.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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