Thermo Fisher Scientific GRAMD1A Polyclonal Antibody
Human 및 Mouse에 반응하는 GRAMD1A 폴리클로날 항체로, Western blot에 적합합니다. KLH 접합 합성 펩타이드(267–296 aa)로부터 제작되었으며, Protein A 및 항원 친화 크로마토그래피로 정제되었습니다. 콜레스테롤 수송 연구 및 자가포식 관련 연구에 활용 가능합니다.
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Applications
- Western Blot (WB): 1:1,000 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 267–296 amino acids from the central region of human GRAMD1A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein A, Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2634111 |
Product Specific Information
Predicted to react with rat based on sequence homology.
Target Information
Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER). Contains unique domains for binding cholesterol and the PM, serving as a molecular bridge for cholesterol transfer from PM to ER. Plays a crucial role in cholesterol homeostasis and localizes to PM or ER depending on membrane cholesterol levels. In lipid-poor conditions, localizes to the ER membrane; under excess cholesterol, recruited to ER–PM contact sites (EPCS) mediated by the GRAM domain. The VASt/ASTER domain binds PM cholesterol to facilitate transfer to ER. May play a role in tumor progression and autophagy regulation, required for autophagosome biogenesis. This autophagy function depends on its cholesterol-transfer activity. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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