Thermo Fisher Scientific EXD2 Polyclonal Antibody

Thermo Fisher Scientific EXD2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

Exonuclease that has both 3′–5′ exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor (PubMed:29335528, PubMed:31127291).
In presence of Mg(2+), only shows 3′–5′ exoribonuclease activity, while it shows both exoribonuclease and exodeoxyribonuclease activities in presence of Mn(2+).
Acts as an exoribonuclease in mitochondrion, possibly by regulating ATP production and mitochondrial translation.
Also involved in the response to DNA damage and plays a key role in controlling chromosomal break repair through its 3′–5′ exonuclease activity.
Required to stabilize and restart stalled replication forks by restraining excessive fork regression, thereby suppressing degradation.
[UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.