Thermo Fisher Scientific EXD2 Polyclonal Antibody
Thermo Fisher Scientific의 EXD2 폴리클로날 항체는 인간, 마우스, 랫트에 반응하며 WB, IHC, ICC, ELISA 등 다양한 응용에 적합합니다. KLH 결합 합성 펩타이드(aa 351-621)로 면역화된 Rabbit IgG 항체로, 고순도 Protein A 정제 및 안정적인 액상 형태로 제공됩니다.
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Thermo Fisher Scientific EXD2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human EXD2, amino acids 351–621 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.03% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Exonuclease that has both 3′–5′ exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor (PubMed:29335528, PubMed:31127291).
In presence of Mg(2+), only shows 3′–5′ exoribonuclease activity, while it shows both exoribonuclease and exodeoxyribonuclease activities in presence of Mn(2+).
Acts as an exoribonuclease in mitochondrion, possibly by regulating ATP production and mitochondrial translation.
Also involved in the response to DNA damage and plays a key role in controlling chromosomal break repair through its 3′–5′ exonuclease activity.
Required to stabilize and restart stalled replication forks by restraining excessive fork regression, thereby suppressing degradation.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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