Thermo Fisher Scientific MAP3K7 Monoclonal Antibody (2E10)

Thermo Fisher Scientific MAP3K7 Monoclonal Antibody (2E10)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MSTASAASSS SSSSAGEMIE APSQVLNFEE IDYKEIEVEE VVGRGAFGVV CKAKWRAKDV AIKQIESESE RKAFIVELRQ LSRVNHPNIV KLYGACLNPV CLVMEYAEGG SLYNVLHGAE PLPYYTAAHA MSWCLQCSQG VAYLHSMQPK ALIHRDLKPP NLLLVAGGTV LKICDFGTAC DIQTHMTNNK GSAAWMAPEV FEGSNYSEKC DVFSWGIILW EVITRRKPFD EIGGPAFRIM WAVHNGTRPP LIKNLPKPIE SLMTRCWSKD PSQRPSMEEI VKIMTHLMRY FPGADEPLQY PCQYSDEGQS NSATSTGSFM DIASTNTSNK SDTNMEQVPA TNDTIKRLES KLLKNQAKQQ SESGRLSLGA SRGSSVESLP PTSEGKRMSA DMSEIEARIA ATTGNGQPRR RSIQDLTVTG TEPGQVSSRS SSPSVRMITT SGPTSEKPTR SHPWTPDDST DTNGSDNSIP MAYLTLDHQL QPLAPCPNSK ESMAVFEQHC KMAQEYMKVQ TEIALLLQRK QELVAELDQD EKDQQNTSRL VQEHKKLLDE NKSLSTYYQQ CKKQLEVIRS QQQKRQGTS

Target Information

TAK1 (also known as MAP3K7) is a serine/threonine kinase involved in multiple signaling pathways.
It functions as a TGF-β-activated kinase interacting with TGF-β receptors and TRAF6 to modulate JNK and p38 activation.
TAK1 also participates in Wnt, BMP, and activin signaling, as well as responses to thyroid hormone, osmotic stress, endothelin, and ephrine.
It regulates wound healing through activation of von Hippel-Lindau tumor suppressor expression and represses PDGF-B, integrin β1, and β5.
TAK1 plays a key role in IKK activation in IL-1, IL-6, IL-18, TNF, CD40, TLR, and RIG-I pathways, requiring TAB2/3 and ubiquitination.
Additionally, TAK1 represses human telomerase reverse transcriptase, suggesting a role in cell lifespan regulation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.