ELK Biotechnology TWEAK rabbit pAb
TWEAK rabbit pAb는 TNFSF12 단백질을 인식하는 다클론 항체로, WB, IHC, IF, ELISA 등에 적합합니다. 인간 및 생쥐 시료에 반응하며, 세포막 및 분비형 단백질 검출에 유용합니다. -20°C에서 1년 보관 가능합니다.
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제품명
TWEAK rabbit pAb
주요 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | TNFSF12; APO3L; DR3LG; Tumor necrosis factor ligand superfamily member 12; APO3 ligand; TNF-related weak inducer of apoptosis; TWEAK |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TNFSF12. AA range: 41-90 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 27 kD |
| GeneID (Human) | 8742 |
| Human Swiss-Prot No | O43508 |
| Cellular Localization | Cell membrane; Single-pass type II membrane protein. [Tumor necrosis factor ligand superfamily member 12, secreted form]: Secreted. [Isoform TWE-PRIL]: Cell membrane; Single-pass membrane protein |
| Species Reactivity | Human; Mouse |
Background
The protein encoded by this gene is a cytokine belonging to the tumor necrosis factor (TNF) ligand family. It acts as a ligand for the FN14/TWEAKR receptor and has overlapping signaling functions with TNF, but exhibits a broader tissue distribution. This cytokine exists in both membrane-bound and secreted forms and can induce apoptosis via multiple pathways in a cell type-specific manner. It also promotes proliferation and migration of endothelial cells, functioning as a regulator of angiogenesis. Alternative splicing produces multiple transcript variants. Some transcripts skip the last exon and continue into the second exon of the neighboring TNFSF13 gene, forming read-through transcripts (GeneID 407977, TNFSF12-TNFSF13). [RefSeq, Oct 2010]
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