ELK Biotechnology TRAP220 rabbit pAb
TRAP220 rabbit polyclonal antibody for detection of MED1 protein in human and mouse samples. Suitable for WB, IHC, IF, and ELISA applications. Recognizes nuclear localization and phosphorylation-dependent behavior. High purity and stable storage at -20...
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ELK Biotechnology TRAP220 Rabbit pAb
제품 개요
TRAP220 rabbit polyclonal antibody는 인간 MED1 단백질을 인식하도록 제작된 항체로, 다양한 면역학적 분석(WB, IHC, IF, ELISA)에 적합합니다. 본 항체는 RNA polymerase II 전사 복합체의 구성 요소인 MED1을 타겟으로 하며, 세포핵 내에 주로 존재합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | TRAP220 rabbit pAb |
| Alternative Names | MED1; ARC205; CRSP1; CRSP200; DRIP205; DRIP230; PBP; PPARBP; PPARGBP; RB18A; TRAP220; TRIP2; Mediator of RNA polymerase II transcription subunit 1; Activator-recruited cofactor 205 kDa component; ARC205; Mediator complex subunit 1; Peroxiso |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human MED1 (AA range: 641–690) |
| Species Reactivity | Human; Mouse |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 170 kD |
| GeneID (Human) | 5469 |
| Human Swiss-Prot No | Q15648 |
| Cellular Localization | Nucleus. A subset of the protein may enter the nucleolus subsequent to phosphorylation by MAPK1 or MAPK3. |
| Storage | -20°C / 1 year |
| Host Species | Rabbit |
Background
The activation of gene transcription is a multistep process triggered by transcriptional enhancer-binding factors. These factors cooperate with co-activators to initiate transcription via RNA polymerase II. The MED1 protein, encoded by this gene, is a subunit of the CRSP complex, essential for SP1 activation, and participates in other multisubunit complexes such as thyroid hormone receptor-associated proteins. It also regulates p53-dependent apoptosis and is critical for adipogenesis. MED1 can self-oligomerize.
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