ELK Biotechnology TIMP-2 rabbit pAb
TIMP-2 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간, 생쥐, 랫드 반응성. 세포외기질 분해 억제 관련 연구에 적합. -20°C에서 1년 보관 가능.
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제품명
TIMP-2 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | TIMP2; Metalloproteinase inhibitor 2; CSC-21K; Tissue inhibitor of metalloproteinases 2; TIMP-2 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 IF: 1/200–1/1000 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TIMP2 (AA range: 21–70) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 25 kDa |
| Gene ID (Human) | 7077 |
| Human Swiss-Prot No. | P16035 |
| Cellular Localization | Secreted |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors and by inhibiting protease activity in tissues undergoing remodeling of the extracellular matrix. (RefSeq, Jul 2008)
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