ELK Biotechnology TIF1α rabbit pAb
TIF1α 단백질을 인식하는 토끼 폴리클로날 항체로, 인간 및 생쥐 시료에 반응합니다. WB, IHC, IF, ELISA에 사용 가능하며, 핵 및 세포질에서 발현되는 TRIM24 단백질 검출에 적합합니다. 합성 펩타이드 면역원으로 제작되었습니다.
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ELK Biotechnology TIF1α rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | TIF1α rabbit pAb |
| Alternative Names | TRIM24; RNF82; TIF1; TIF1A; Transcription intermediary factor 1-alpha; TIF1-alpha; E3 ubiquitin-protein ligase TRIM24; RING finger protein 82; Tripartite motif-containing protein 24 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TRIM24. AA range: 1001–1050 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 117 kD |
| GeneID (Human) | 8805 |
| Human Swiss-Prot No | O15164 |
| Cellular Localization | Nucleus, Cytoplasm, Mitochondrion. Colocalizes with sites of active transcription. Detected both in nucleus and cytoplasm in some breast cancer samples. Predominantly nuclear. Translocated from nucleus to mitochondria to mediate antiviral immunity (PubMed:32324863). |
| Species Reactivity | Human; Mouse |
Background
The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains — a RING, a B-box type 1 and a B-box type 2 — and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
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