ELK Biotechnology TGFβ3 rabbit pAb
TGFβ3 단백질을 인식하는 토끼 다클론 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간, 마우스, 랫드, 원숭이에 반응. 합성 펩타이드 기반 면역원으로 제작되었으며, 세포외 분비 단백질 연구에 적합. -20°C에서 1년 보관 가능.
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제품명
TGFβ3 rabbit pAb
제품 개요
TGFβ3 단백질을 인식하는 토끼 다클론 항체로, 다양한 종에서의 TGF-beta 신호전달 연구 및 단백질 발현 분석에 활용됩니다. 합성 펩타이드(AA 261–310)를 면역원으로 사용하였으며, Western blot, IHC, IF, ELISA 등 다양한 응용에 적합합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | TGFβ3 rabbit pAb |
| Alternative Names | TGFB3; Transforming growth factor beta-3; TGF-beta-3 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human TGF beta3 (AA range: 261–310) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 13 kDa |
| Gene ID (Human) | 7043 |
| Human Swiss-Prot No. | P10600 |
| Cellular Localization | [Latency-associated peptide]: Secreted, extracellular space, extracellular matrix [Transforming growth factor beta-3]: Secreted |
| Species Reactivity | Human; Mouse; Rat; Monkey |
Background
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression.
The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form (composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein) or in an active form (consisting solely of the mature peptide homodimer).
The mature peptide may also form heterodimers with other TGF-beta family members. This protein is involved in embryogenesis and cell differentiation, and may play a role in wound healing. Mutations in this gene are a cause of aortic aneurysms and dissections, as well as familial arrhythmogenic conditions.
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