ELK Biotechnology TGFβ RI rabbit pAb
TGFβ RI rabbit pAb는 인간, 마우스, 랫트에서 반응하는 폴리클로날 항체로, WB, IF, ELISA에 사용 가능. 세포막 단백질 TGFβ 수용체 I을 인식하며, 신호전달 연구에 적합. -20°C에서 1년 보관 가능.
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제품명
TGFβ RI rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | TGFBR1; ALK5; SKR4; TGF-beta receptor type-1; TGFR-1; Activin A receptor type II-like protein kinase of 53kD; Activin receptor-like kinase 5; ALK-5; ALK5; Serine/threonine-protein kinase receptor R4; SKR4; TGF-beta type I receptor; Transforming growth factor beta receptor I |
| Applications | WB; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000; IHC-p: 1/100–1/300; ELISA: 1/20000; IF: 1/100–1/300 (other applications not yet tested) |
| Immunogen | Synthesized peptide derived from human TGF beta Receptor I (AA range: 131–180) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 56 kD |
| Gene ID (Human) | 7046 |
| Human Swiss-Prot No. | P36897 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein; Cell junction (tight junction); Cell surface; Membrane raft |
| Species Reactivity | Human; Mouse; Rat |
Background
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene.
[provided by RefSeq, Aug 2008]
참고 문헌
BIOCHIMICA ET BIOPHYSICA ACTA - MOLECULAR CELL RESEARCH
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