ELK Biotechnology MMP-3 rabbit pAb
MMP-3 rabbit polyclonal antibody로 인간, 마우스, 랫트 시료에서 반응. WB, IHC, IF, ELISA 등 다양한 응용 가능. 인간 MMP-3 유래 합성 펩타이드로 면역생성. 세포외 기질 분해 관련 연구에 적합. -20°C에서 1년 보관 가능.
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제품명
MMP-3 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | MMP3; STMY1; Stromelysin-1; SL-1; Matrix metalloproteinase-3; MMP-3; Transin-1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MMP-3 (AA range: 421–470) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 53 kD |
| GeneID (Human) | 4314 |
| Human Swiss-Prot No | P08254 |
| Cellular Localization | Secreted, extracellular space, extracellular matrix |
| Species Reactivity | Human; Mouse; Rat |
Background
Matrix metallopeptidase 3 (MMP3) is a member of the MMP family involved in extracellular matrix breakdown during physiological processes such as embryonic development, reproduction, and tissue remodeling, as well as in pathological processes including arthritis and metastasis. Most MMPs are secreted as inactive proproteins activated by extracellular proteinases. MMP3 degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. It plays roles in wound repair, atherosclerosis progression, and tumor initiation. The MMP3 gene is part of a cluster located on chromosome 11q22.3.
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