ELK Biotechnology Stat5a rabbit pAb

제품명

Stat5a rabbit pAb

제품 개요

STAT5A는 사이토카인 및 성장인자 자극에 반응하여 인산화되고, 핵으로 이동해 전사 활성화 역할을 하는 전사 인자입니다. 본 항체는 인간 STAT5A 유래 펩타이드(AA 745-794)에 대해 생산된 토끼 폴리클로날 항체로, 세포 내 신호전달 및 전사 조절 연구에 유용합니다.

제품 정보

Background

The protein encoded by this gene belongs to the STAT family of transcription factors. Upon cytokine or growth factor stimulation, STAT proteins are phosphorylated by receptor-associated kinases, form homo- or heterodimers, and translocate to the nucleus to act as transcription activators. STAT5A mediates responses to multiple ligands, including IL2, IL3, IL7, GM-CSF, erythropoietin, thrombopoietin, and various growth hormones. Constitutive activation of STAT5A, such as through TEL/JAK2 fusion, is linked to tumorigenesis in myeloma and lymphoma. In mice, STAT5A induces BCL2L1/BCL-X(L) expression, suggesting an anti-apoptotic role. Alternatively spliced transcript variants have been identified.