ELK Biotechnology Stat2 rabbit pAb
STAT2 단백질을 인식하는 토끼 다클론 항체로, WB, IHC, IF, ELISA 등 다양한 응용에 적합합니다. 인간 STAT2 유래 펩타이드로 면역화되었으며, 세포질 및 핵에서 발현을 검출할 수 있습니다. 고순도 IgG, 1 mg/ml 농도로 제공됩니다.
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ELK Biotechnology Stat2 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Stat2 rabbit pAb |
| Alternative Names | STAT2; Signal transducer and activator of transcription 2; p113 |
| Applications | WB; IP; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human STAT2. AA range: 656–705 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 113 kDa |
| GeneID (Human) | 6773 |
| Human Swiss-Prot No | P52630 |
| Cellular Localization | Cytoplasm, Nucleus. Translocated into the nucleus upon activation by IFN-alpha/beta. |
| Species Reactivity | Human; Mouse; Rat |
Background
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor-associated kinases and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), acting as a transactivator but lacking direct DNA-binding ability. Transcription adaptor P300/CBP (EP300/CREBBP) interacts specifically with this protein, which is thought to be involved in blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [Provided by RefSeq, Mar 2010]
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