ELK Biotechnology SMAP45 rabbit pAb
HDAC3 단백질을 인식하는 SMAP45 rabbit polyclonal antibody. WB, IHC, IF, ELISA에 적합하며 인간, 마우스, 랫트, 원숭이에 반응. 핵 및 세포질에서 발현되는 HDAC3 연구에 적합한 고품질 항체.
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제품명
SMAP45 rabbit pAb
공급업체
ELK Biotechnology
제품 개요
SMAP45 rabbit polyclonal antibody는 인간 HDAC3 단백질을 타겟으로 제작된 항체로, 다양한 응용 분야에서 사용 가능합니다. Histone deacetylase 3는 전사 조절, 세포주기 진행, 발달 과정에 중요한 역할을 하는 단백질로 알려져 있습니다.
제품 스펙
| 항목 | 내용 |
|---|---|
| Alternative Names | HDAC3; Histone deacetylase 3; HD3; RPD3-2; SMAP45 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 Immunofluorescence: 1/200–1/1000 ELISA: 1/20000 Other applications not tested |
| Immunogen | Synthesized peptide derived from human HDAC3 (AA range: 379–428) |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 50 kD |
| GeneID (Human) | 8841 |
| Human Swiss-Prot No | O15379 |
| Cellular Localization | Nucleus; Cytoplasm; Cytoplasm, cytosol. Colocalizes with XBP1 and AKT1 in cytoplasm (PubMed:25190803). Predominantly expressed in nucleus with CCAR2 (PubMed:21030595). |
| Species Reactivity | Human; Mouse; Rat; Monkey |
Background
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The HDAC3 protein belongs to the histone deacetylase/acuc/apha family and represses transcription when tethered to a promoter. It may regulate transcription through interaction with YY1 and can down-regulate p53 function, thus influencing cell growth and apoptosis. This gene is regarded as a potential tumor suppressor (RefSeq, Jul 2008).
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