ELK Biotechnology Smad1/5/9 rabbit pAb
Smad1/5/9 rabbit polyclonal antibody로 BMP 신호전달 관련 단백질 검출에 적합. WB, IHC, IF, ELISA 등 다양한 응용 가능. 인간, 마우스, 랫트 반응성. 고순도 IgG 항체로 세포질 및 핵 위치 단백질 분석에 유용.
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제품명
Smad1/5/9 rabbit pAb
공급업체
ELK Biotechnology
제품 개요
Smad1/5/9 rabbit polyclonal antibody는 BMP 신호전달 경로의 핵심 단백질을 검출하기 위한 항체로, 세포 성장, 분화, 형태형성, 면역 반응 연구에 활용됩니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | SMAD1; BSP1; MADH1; MADR1; Mothers against decapentaplegic homolog 1; MAD homolog 1; Mothers against DPP homolog 1; JV4-1; Mad-related protein 1; SMAD family member 1; SMAD 1; Smad1; hSMAD1; Transforming growth factor-beta-signaling protein |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 ELISA: 1/10000 Other applications: Not yet tested |
| Immunogen | Synthesized peptide derived from human Smad1/5/9 (AA range: 10–59) |
| Species Reactivity | Human; Mouse; Rat |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 56 kDa |
| GeneID (Human) | 4086 / 4090 / 4093 |
| Human Swiss-Prot No | Q15797 / Q99717 / O15198 |
| Cellular Localization | Cytoplasm and nucleus. Cytoplasmic in the absence of ligand; migrates to nucleus when complexed with SMAD4. Co-localizes with LEMD3 at nuclear inner membrane. Exported to cytoplasm when dephosphorylated. |
Background
The protein encoded by this gene belongs to the SMAD family, which is homologous to the Drosophila gene mothers against decapentaplegic (Mad) and the C. elegans gene Sma. SMAD proteins act as signal transducers and transcriptional modulators, mediating multiple signaling pathways. Smad1/5/9 mediates BMP signals involved in cell growth, apoptosis, morphogenesis, development, and immune responses. Upon BMP ligand stimulation, it is phosphorylated and activated by BMP receptor kinase, forming a complex with SMAD4 to regulate transcription. It is also targeted by SMAD-specific E3 ubiquitin ligases (SMURF1, SMURF2) for ubiquitination and proteasomal degradation.
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