ELK Biotechnology SH-PTP2 rabbit pAb
Human SHP-2 단백질을 인식하는 rabbit polyclonal antibody로, WB, IHC, IF, ELISA에 적합합니다. 세포 성장 및 신호전달 연구에 활용되며, 사람·생쥐·랫트 시료에 반응합니다. 고순도 IgG로 -20°C에서 1년간 안정적으로 보관 가능합니다.
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제품명
SH-PTP2 rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | PTPN11; PTP2C; SHPTP2; Tyrosine-protein phosphatase non-receptor type 11; Protein-tyrosine phosphatase 1D; PTP-1D; Protein-tyrosine phosphatase 2C; PTP-2C; SH-PTP2; SHP-2; Shp2; SH-PTP3 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human SHP-2 (AA range: 546–595) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 72 kD |
| GeneID (Human) | 5781 |
| Human Swiss-Prot No. | Q06124 |
| Cellular Localization | Cytoplasm, Nucleus |
| Species Reactivity | Human, Mouse, Rat |
Background
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate various cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.
This PTP contains two tandem Src homology-2 domains, functioning as phospho-tyrosine binding domains and mediating interaction with its substrates. It is widely expressed in most tissues and plays a regulatory role in diverse cell signaling events such as mitogenic activation, metabolic control, transcription regulation, and cell migration.
Mutations in this gene are associated with Noonan syndrome and acute myeloid leukemia. (RefSeq, Aug 2016)
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