ELK Biotechnology SEMA4A rabbit pAb
SEMA4A rabbit polyclonal antibody로 인간, 마우스, 랫트, 원숭이에 반응합니다. WB, IHC, IF, ELISA에 사용 가능하며 다양한 희석 범위로 적용됩니다. 세포막 단백질 검출에 적합하며 면역 및 신경 관련 연구에 유용합니다.
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제품명
SEMA4A rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | SEMA4A; SEMAB; SEMB; Semaphorin-4A; Semaphorin-B; Sema B |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human SEMA4A (AA range: 501–550) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 84 kDa |
| Gene ID (Human) | 64218 |
| Human Swiss-Prot No | Q9H3S1 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein |
| Species Reactivity | Human; Mouse; Rat; Monkey |
Background
This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions including axon guidance, morphogenesis, carcinogenesis, and immunomodulation.
The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain, and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.
It acts as an activator of T-cell-mediated immunity and suppresses VEGF-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo.
Mutations in this gene are associated with retinal degenerative diseases such as retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
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