ELK Biotechnology Rpb1 rabbit pAb
RNA polymerase II의 가장 큰 소단위체 Rpb1을 인식하는 rabbit polyclonal antibody로, WB, IHC, IF, ELISA에 적합합니다. 인간 POLR2A 유래 펩타이드로 면역 생성되었으며, 핵과 세포질에서 발현되는 단백질 검출에 활용 가능합니다.
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제품명
Rpb1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Rpb1 rabbit pAb |
| Alternative Names | POLR2A; POLR2; DNA-directed RNA polymerase II subunit RPB1; RNA polymerase II subunit B1; DNA-directed RNA polymerase II subunit A; DNA-directed RNA polymerase III largest subunit; RNA-directed RNA polymerase II subunit RPB1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 Immunofluorescence: 1/200–1/1000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human POLR2A (AA range: 1585–1634) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 250 kDa |
| Gene ID (Human) | 5430 |
| Human Swiss-Prot No. | P24928 |
| Cellular Localization | Nucleus, Cytoplasm, Chromosome. Hypophosphorylated form mainly in cytoplasm; hyperphosphorylated and active form in nucleus (PubMed:26566685). Co-localizes with kinase SRPK2 and helicase DDX23 at chromatin loci where unscheduled R-loops form (PubMed:28076779). |
| Species Reactivity | Human, Mouse, Rat, Monkey |
Background
This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008]
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