ELK Biotechnology Rho A rabbit pAb
Rho A 단백질을 인식하는 토끼 폴리클로날 항체로, IF, WB, IHC, ELISA에 사용 가능. 인간 RhoA 유래 합성 펩타이드로 면역화됨. 세포막 및 세포골격 위치 검출에 적합하며, 종간 반응성은 Human, Mouse, Rat에서 확인됨.
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Rho A rabbit pAb
제품 개요
RhoA 단백질을 인식하는 토끼 폴리클로날 항체로, 세포막 및 세포골격 관련 연구에 적합합니다. 인간 RhoA 유래 합성 펩타이드(AA 144-193)를 면역원으로 제작되었습니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product Name | Rho A rabbit pAb |
| Alternative Names | RHOA; ARH12; ARHA; RHO12; Transforming protein RhoA; Rho cDNA clone 12; h12 |
| Applications | IF; WB; IHC; ELISA |
| Recommended Dilutions | IF: 1:50–200; WB: 1:500–1:2000; IHC: 1:100–1:300; ELISA: 1:5000. Other applications not yet tested. |
| Immunogen | Synthesized peptide derived from human RhoA (AA range: 144–193) |
| Host Species | Rabbit |
| Storage | −20 °C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 22 kDa |
| Gene ID (Human) | 387 |
| Human Swiss-Prot No. | P61586 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치
Cell membrane (lipid-anchor, cytoplasmic side), cytoplasm, cytoskeleton, cleavage furrow, cell cortex, midbody, lamellipodium, dendrite, nucleus.
Localized to cell-cell contacts in calcium-treated keratinocytes (By similarity).
Translocates to the equatorial region before furrow formation in an ECT2-dependent manner.
Localizes to the equatorial cell cortex (site of presumptive furrow) in early anaphase in an activated form, independent of myosin and actin.
Background
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades.
Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility.
Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified.
(Provided by RefSeq, Sep 2015)
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