ELK Biotechnology Rad50 rabbit pAb
RAD50 단백질을 인식하는 토끼 폴리클로날 항체로, 인간 RAD50 유래 합성 펩타이드로 면역화됨. WB, IHC, IF, ELISA에 사용 가능하며 핵 및 염색체에 위치. DNA 이중가닥 절단 복구 연구에 적합.
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제품명
Rad50 rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | RAD50; DNA repair protein RAD50; hRAD50 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human RAD50 (AA range: 681–730) |
| Species | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 153 kD |
| GeneID (Human) | 10111 |
| Human Swiss-Prot No | Q92878 |
| Cellular Localization | Nucleus; Chromosome; Telomere. Localizes to discrete nuclear foci after treatment with genotoxic agents. |
| Species Reactivity | Human; Mouse; Rat |
Background
RAD50 double strand break repair protein (RAD50) Homo sapiens.
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays enzymatic activities required for nonhomologous joining of DNA ends.
Together with its partners, RAD50 is essential for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination.
Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene cause Nijmegen breakage syndrome-like disorder.
(Provided by RefSeq, Apr 2010)
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