ELK Biotechnology Rac1/2/3/CDC42 rabbit pAb
Rac1/2/3/CDC42 rabbit polyclonal antibody로, 세포 성장 및 골격 재구성 관련 GTPase 단백질 검출에 사용됩니다. WB, IHC, IF, ELISA에 적합하며, 사람·마우스·랫트 시료에서 반응합니다. 고순도 IgG, -20°C 보관 안정성 우수.
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Rac1/2/3/CDC42 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Rac1/2/3/CDC42 rabbit pAb |
| Alternative Names | RAC1; TC25; MIG5; Ras-related C3 botulinum toxin substrate 1; Cell migration-inducing gene 5 protein; Ras-like protein TC25; p21-Rac1; RAC2; Ras-related C3 botulinum toxin substrate 2; GX; Small G protein; p21-Rac2; RAC3; Ras-related C3 bot |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Rac1/CDC42 (AA range: 38–87) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 26 kD |
| Gene ID (Human) | 5879 / 5880 / 5881 / 998 |
| Human Swiss-Prot No | P63000 / P15153 / P60763 / P60953 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치 (Cellular Localization)
Cell membrane; Lipid-anchor; Cytoplasmic side; Melanosome; Cytoplasm; Cell projection (lamellipodium, dendrite); Cell junction (synapse); Nucleus.
Located on the inner surface of the plasma membrane, possibly requiring prenylation of the C-terminal cysteine (PubMed:1903399).
Identified by mass spectrometry in melanosome fractions (stage I–IV, PubMed:17081065).
Found in the ruffled border of bone-resorbing osteoclasts and localizes to the lamellipodium in a SH3RF1-dependent manner.
In macrophages, cytoplasmic localization increases upon CSF1 stimulation.
Activation by GTP-binding promotes nuclear localization (PubMed:12551911).
Background
The protein encoded by this gene is a GTPase belonging to the RAS superfamily of small GTP-binding proteins.
Members of this superfamily regulate diverse cellular events, including cell growth control, cytoskeletal reorganization, and activation of protein kinases.
Two transcript variants encoding different isoforms have been identified for this gene.
[Provided by RefSeq, Mar 2009]
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