ELK Biotechnology PYK2 rabbit pAb
인간 PYK2 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 칼슘 의존적 타이로신 키나아제 연구에 적합하며, 세포막 및 세포질에서 발현. -20°C에서 1년 보관 가능.
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제품명
PYK2 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | PTK2B; FAK2; PYK2; RAFTK; Protein-tyrosine kinase 2-beta; Calcium-dependent tyrosine kinase; CADTK; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; CAK-beta; CAKB; Focal adhesion kinase 2; FADK 2 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human PYK2 (AA range: 546–595) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 115 kDa |
| Gene ID (Human) | 2185 |
| Human Swiss-Prot No. | Q14289 |
| Species Reactivity | Human; Mouse; Rat; Monkey |
| Cellular Localization | Cytoplasm; perinuclear region; cell membrane (cytoplasmic side); focal adhesion; lamellipodium; cell cortex; nucleus. Interaction with NPHP1 induces membrane association. Colocalizes with integrins at the cell periphery. |
Background
This gene encodes a cytoplasmic protein tyrosine kinase involved in calcium-induced regulation of ion channels and activation of the MAP kinase signaling pathway. The encoded protein acts as a signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and downstream signals regulating neuronal activity. It undergoes rapid tyrosine phosphorylation and activation in response to increased intracellular calcium, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein binds CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. It belongs to the FAK subfamily of protein tyrosine kinases.
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