ELK Biotechnology PUMA rabbit pAb
인간, 생쥐, 랫트에서 반응하는 PUMA 단백질 특이 토끼 폴리클로날 항체. WB, IF, ELISA에 적합하며 미토콘드리아에서 사이토크롬 c 방출 유도 연구에 활용. 암 및 세포사멸 관련 연구에 유용.
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ELK Biotechnology PUMA rabbit pAb
제품 개요
PUMA rabbit pAb는 인간 PUMA 단백질을 인식하는 토끼 폴리클로날 항체로, 세포사멸(apoptosis) 연구에 적합합니다. 본 항체는 미토콘드리아에서 사이토크롬 c 방출을 유도하는 BCL-2 계열 단백질 연구에 활용됩니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product Name | PUMA rabbit pAb |
| Alternative Names | BBC3; PUMA; Bcl-2-binding component 3; JFY-1; p53 up-regulated modulator of apoptosis |
| Applications | WB, IF, ELISA |
| Recommended Dilutions | WB: 1:500–2000 IF: 1:100–300 ELISA: 1:5000–20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human PUMA (AA range: 120–169) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 23 kD |
| Gene ID (Human) | 27113 |
| Human Swiss-Prot No. | Q9BXH1 |
| Cellular Localization | Mitochondrion. Localized to the mitochondria to induce cytochrome c release. |
| Species Reactivity | Human, Mouse, Rat |
Background
This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. (RefSeq, Dec 2011)
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