ELK Biotechnology PTP1B rabbit pAb
PTP1B 단백질에 특이적인 rabbit polyclonal antibody로, WB, IHC, IF, ELISA 등에 사용 가능. 인간, 마우스, 랫트, 원숭이 반응성. 고순도 IgG 형식으로 세포 내 신호 조절 연구에 적합. -20°C에서 1년 보관 가능.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology PTP1B rabbit pAb
제품명
PTP1B rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | PTPN1; PTP1B; Tyrosine-protein phosphatase non-receptor type 1; Protein-tyrosine phosphatase 1B; PTP-1B |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PTP1B (AA range: 16–65) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 49 kD |
| Gene ID (Human) | 5770 |
| Human Swiss-Prot No | P18031 |
| Cellular Localization | Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Interacts with EPHA3 at the cell membrane. |
| Species Reactivity | Human; Mouse; Rat; Monkey |
Background
The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, essential for catalytic activity. PTPs are signaling molecules that regulate various cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.
This PTP acts as a negative regulator of insulin signaling by dephosphorylating phosphotyrosine residues of the insulin receptor kinase. It also dephosphorylates epidermal growth factor receptor kinase, JAK2, and TYK2 kinases, implicating its role in signal transduction regulation.
ELK Biotechnology 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.