ELK Biotechnology PSMD12 rabbit pAb
PSMD12 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간 PSMD12 합성 펩타이드(AA 151–200)로 면역 생성. 고순도 IgG, 1 mg/ml 농도. -20°C에서 1년 보관 가능.
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PSMD12 rabbit pAb
제품 개요
PSMD12 단백질을 인식하는 토끼 폴리클로날 항체로, 다양한 면역학적 분석(WB, IHC, IF, ELISA)에 적합합니다. 인간 PSMD12 유래 펩타이드(AA 151–200)를 면역원으로 사용하여 제작되었습니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | PSMD12 rabbit pAb |
| Alternative Names | PSMD12; 26S proteasome non-ATPase regulatory subunit 12; 26S proteasome regulatory subunit RPN5; 26S proteasome regulatory subunit p55 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human PSMD12 (AA range: 151–200) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 50 kD |
| GeneID (Human) | 5718 |
| Human Swiss-Prot No | O00232 |
| Cellular Localization | Proteasome complex, nucleoplasm, cytoplasm, cytosol, proteasome regulatory particle, lid subcomplex, membrane, proteasome accessory complex, nuclear proteasome complex, extracellular exosome |
| Species Reactivity | Human; Mouse; Rat |
Background
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of two complexes — a 20S core and a 19S regulator.
The 20S core consists of four rings of 28 non-identical subunits: two rings of seven alpha subunits and two rings of seven beta subunits.
The 19S regulator includes a base with six ATPase subunits and two non-ATPase subunits, and a lid containing up to ten non-ATPase subunits.
Proteasomes are widely distributed in eukaryotic cells and cleave peptides in an ATP/ubiquitin-dependent, non-lysosomal pathway.
A modified version, the immunoproteasome, plays a key role in processing class I MHC peptides.
This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3. Alternatively spliced transcript variants are known.
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