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ELK Biotechnology Pinin rabbit pAb
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Human PNN 단백질에 대한 rabbit polyclonal antibody로, WB 및 IHC에 적합. 핵 및 세포접촉 부위에 발현되는 Pinin 단백질 검출에 사용. 고순도 IgG 형태로 -20°C에서 1년 보관 가능.
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ELK Biotechnology ES3210-100UL Pinin rabbit pAb, 100UL pk판매 단위 pk ·
재고 확인 필요
402,000원VAT 포함 442,200원
ELK Biotechnology ES3210-50UL Pinin rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology Pinin rabbit pAb
ELK Biotechnology Pinin rabbit pAb
제품 개요
ELK Biotechnology의 Pinin rabbit polyclonal antibody는 인간 PNN 단백질을 인식하는 항체로, Western blot(WB) 및 Immunohistochemistry(IHC)에 사용됩니다. 세포 접착 및 핵 내 스플라이싱 관련 연구에 적합합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Pinin rabbit pAb |
| Alternative Names | PNN; DRS; MEMA; Pinin; 140 kDa nuclear and cell adhesion-related phosphoprotein; Desmosome-associated protein; Domain-rich serine protein; DRS protein; DRSP; Melanoma metastasis clone A protein; Nuclear protein SDK3; SR-like protein |
| Applications | WB; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300 |
| Immunogen | Synthesized peptide derived from human PNN (AA range: 211–260) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 85 kDa |
| GeneID (Human) | 5411 |
| Human Swiss-Prot No | Q9H307 |
| Species Reactivity | Human; Mouse |
| Cellular Localization | Nucleus speckle; Cell junction (desmosome); Cell-cell contact area, predominantly desmosome of intercellular adherens junction. Not a nucleocytoplasmic shuttling protein. |
Background
- Function: Transcriptional activator binding to the E-box 1 core sequence (5’CAGGTG-3’) of the E-cadherin promoter gene; capable of reversing CTBP1-mediated transcription repression. Also participates in regulation of alternative pre-mRNA splicing and associates with spliced mRNA near 5’-splice sites. Involved in epithelial cell-cell adhesion and may act as a tumor suppressor in renal cell carcinoma.
- Post-translational Modification (PTM): Phosphorylated upon DNA damage, likely by ATM or ATR.
- Similarity: Belongs to the pinin family.
- Subcellular Location: Cell-cell contact area, predominantly desmosome of intercellular adherens junction. Not a nucleocytoplasmic shuttling protein.
- Subunit: Found in complexes with SR proteins and mRNP complexes with RNPS1. Interacts with multiple proteins including CTBP1, CTBP2, KRT8, KRT18, KRT19, PPIG, RNPS1, SFRS4, SRRM2, and others. Identified in spliceosome C complex.
- Tissue Specificity: Expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, epidermis, esophagus, brain, and muscle. Strongly expressed in melanoma metastasis lesions and advanced primary tumors.
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