ELK Biotechnology PHLDA3 rabbit pAb
PHLDA3 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 적합합니다. 인간 유래 합성 펩타이드(AA 21-70)를 면역원으로 제작되었으며, 세포질 및 세포막 주변에 위치한 PHLDA3 단백질 검출에 유용합니다. -20°C에서 1년 보관 가능합니다.
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ELK Biotechnology PHLDA3 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | PHLDA3 rabbit pAb |
| Alternative Names | PHLDA3; TIH1; Pleckstrin homology-like domain family A member 3; TDAG51/Ipl homolog 1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PHLDA3 (AA range: 21–70) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 15 kD |
| GeneID (Human) | 23612 |
| Human Swiss-Prot No | Q9Y5J5 |
| Cellular Localization | Cytoplasm; Membrane; Peripheral membrane protein |
| Species Reactivity | Human; Mouse; Rat |
Background
The PH domain of PHLDA3 binds phosphoinositides with broad specificity and competes with the PH domain of AKT1, interfering with AKT1 binding to PIP2 and PIP3. This prevents AKT1 association with membrane lipids and subsequent activation of AKT1 signaling.
PHLDA3 is a p53/TP53-regulated repressor of AKT1 signaling, contributing to p53-dependent apoptosis by repressing AKT1 activity. Expression is directly activated by p53/TP53, and phosphorylation on Ser-15 is required for PHLDA3 promoter activation.
The PHLDA3 genomic locus is frequently altered in primary lung cancers, suggesting a tumor suppressor role. It belongs to the PHLDA3 family and contains one PH domain. Expression is widespread, with the lowest levels in liver and spleen.
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