ELK Biotechnology PDGFR-β rabbit pAb
PDGFR-β 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며 세포막 및 세포소기관 내 PDGFR-β 발현 분석에 유용합니다. -20°C에서 1년 보관 가능합니다.
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ELK Biotechnology PDGFR-β rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | PDGFR-β rabbit pAb |
| Alternative Names | PDGFRB; PDGFR; PDGFR1; Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-beta; Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC-p: 1/100–1/300 ELISA: 1/20000 IF: 1/100–1/300 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human PDGF Receptor beta (AA range: 718–767) |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 135–180 kDa |
| GeneID (Human) | 5159 |
| Human Swiss-Prot No. | P09619 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein; Cytoplasmic vesicle; Lysosome lumen. After ligand binding, the autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation. |
| Storage | -20°C / 1 year |
Background
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor (PDGF) family. These growth factors act as mitogens for cells of mesenchymal origin. The receptor’s ligand-binding identity determines whether it forms a homodimer or heterodimer with PDGFR-α or PDGFR-β polypeptides. The gene is located on chromosome 5 near GM-CSF and M-CSF receptor genes, potentially linked to the 5q syndrome. A translocation between chromosomes 5 and 12 that fuses this gene with the ETV6 leukemia gene results in chronic myeloproliferative disorder with eosinophilia (RefSeq, Jul 2008).
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