Thermo Fisher Scientific TRAIL-R2 (DR5) Monoclonal Antibody (DR-5-01-1), FITC
인간 TRAIL-R2(DR5) 단백질의 세포외 도메인을 인식하는 단클론 항체로, FITC 결합을 통해 유세포분석(Flow Cytometry)에 적합함. 498/517 nm 형광 특성을 가지며, 액상 형태로 제공되고 4°C 암소 저장. 연구용으로만 사용 가능.
- 카탈로그번호
- A15750
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Applications
- Flow Cytometry (Flow)
Tested Dilution: 1–5 µg/mL
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | DR-5-01-1 |
| Immunogen | Recombinant fusion protein of human IgG heavy chain and extracellular domain of DR5 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2534530 |
Product Specific Information
This antibody recognizes an extracellular domain of TRAIL-R2 (DR5). TRAIL-R2 is one of two TNF superfamily members that contain a death domain for TRAIL (APO2L).
Target Information
DR5 (Apo2, TRAIL-R2, TRICK2, KILLER) is a death domain-containing receptor for TRAIL, mediating TRAIL-induced apoptosis. It belongs to the TNF-receptor superfamily and transduces apoptosis signals through TNFSF10/TRAIL/APO-2L activation.
FADD adaptor protein is required for DR5-mediated apoptosis. Two transcript variants encoding different isoforms and one non-coding transcript have been identified. Overexpression of DR5 induces apoptosis and activates NF-κB.
DR5 is expressed in various cell types, particularly in lymphocytes and spleen. Dysfunctions are associated with squamous cell carcinoma and diffuse infiltrative lymphocytosis syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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