Thermo Fisher Scientific CD80 Recombinant Rabbit Monoclonal Antibody (BLR206K)
Recombinant rabbit monoclonal antibody targeting human CD80 (B7-1). Validated for WB, IHC(P), and Flow applications. High purity, unconjugated form, concentration 1 mg/mL. Recommended for research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Flow Cytometry (Flow) | 0.25 µL / 10^6 cells |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | BLR206K |
| Immunogen | Recombinant protein representing the extracellular domain of Human T-lymphocyte activation antigen CD80 (residues 35–246) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Purified |
| Storage Buffer | BBS, pH 8.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For immunohistochemistry, epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.
- Extended primary antibody incubation (16–24 hours) is recommended.
Target Information
CD80 (B7-1) and CD86 (B7-2) are ligands of the T cell costimulatory molecule CD28 and the inhibitory receptor CTLA-4 (CD152). Both are expressed on professional antigen-presenting cells and are essential for T cell activation.
CD80 is rapidly induced on the surface of activated B cells, EBV-transformed B cell lines, Burkitt’s lymphoma cell lines, and follicular B lymphoma cells, as well as T cells and monocytes.
The B-lymphocyte activation antigen B7-1 provides regulatory signals for T lymphocytes through binding to CD28 and CTLA-4.
Diseases associated with CD80 dysfunction include gallbladder squamous cell carcinoma and myocarditis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: A700-206_CD80_B7-1_P33681-1_Rabbit.svg, A700-206_CD80_B7-1_P33681-1_Rabbit_PDP.jpeg)
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