Thermo Fisher Scientific Human GBL Synthetic Peptide
인간 GBL 단백질의 C-말단 14개 아미노산 서열에 해당하는 합성 펩타이드. PA5-20127 항체의 블로킹 펩타이드로 사용 가능. mTOR 신호전달 복합체 연구 및 세포 성장 조절 관련 연구에 적합. 연구용 한정 제품.
- 카탈로그번호
- PEP0245
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 14 amino acids near the carboxy terminus of human GbL.
PEP-0245 can be used as a blocking peptide with polyclonal antibody PA5-20127.
Target Information
G-protein beta subunit like (GBL protein) is a novel member of the WD-40 protein family. It is a highly conserved cytosolic protein consisting of seven WD-40 repeating motifs. LST8 is a functional component of the mTOR signaling complex (TORC1) and positively regulates the mTOR pathway. It interacts with the kinase domain of mTOR and stabilizes its interaction with raptor. LST8 participates in regulating cell growth and in nutrient and growth factor-mediated mTOR signaling to S6K1. Reports suggest up-regulated expression of LST8 due to insulin, indicating a possible role in intracellular events related to insulin-receptor activation, including insulin-stimulated glucose transport and glycogen synthesis. Northern blot analysis detected ubiquitous expression of LST8, with highest expression in brain and testis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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