Thermo Fisher Scientific Cdc73 Recombinant Rabbit Monoclonal Antibody (23GB3450)
Cdc73 단백질을 표적하는 재조합 토끼 단클론 항체로, Western blot, ICC/IF, Flow cytometry에 사용 가능. 인간, 생쥐, 랫트 반응성. HEK293F 발현 시스템 기반, 액상 형태로 친화 크로마토그래피 정제. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
| Flow Cytometry (Flow) | 1:2,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB3450 |
| Immunogen | A synthetic peptide of human HRPT2/CDC73 (350–400AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
Cdc73 is a tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. It is part of the PAF1 complex, a five-subunit protein complex composed of Paf1, Cdc73, Leo1, Rtf1, and Ctr9. PAF1 was first purified from yeast in association with RNA polymerase II and is believed to function in transcription elongation. The yeast PAF (yPAF) complex interacts with RNA polymerase II and coordinates the setting of histone marks associated with active transcription. In addition to coordinating events during transcription (initiation, promoter clearance, and elongation), hPAF also coordinates events in RNA quality control. Cdc73 may also be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: MA5-53424_CDC73_Q6P1J9-1_Rabbit_PDP.jpeg, MA5-53424_CDC73_Q6P1J9-1_Rabbit.svg)
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