Thermo Fisher Scientific PSMA Monoclonal Antibody (A5G5)
PSMA 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western blot 및 IHC(Paraffin) 실험에 적합합니다. 인간 시료에 반응하며, Protein G로 정제된 액상 형태입니다. 단기 4°C, 장기 -20°C 보관을 권장합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | A5G5 |
| Immunogen | Recombinant protein within human PSMA aa 30–750/750 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Protein G |
| Storage Buffer | TBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2931441 |
Target Information
This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different substrates, including folate and the neuropeptide N-acetyl-L-aspartyl-L-glutamate. It is expressed in tissues such as prostate, central and peripheral nervous system, and kidney. Mutations may cause impaired intestinal absorption of dietary folates, leading to low blood folate levels and hyperhomocysteinemia. In the brain, expression may be linked to glutamate excitotoxicity-related conditions. In the prostate, the protein is upregulated in cancerous cells and serves as a diagnostic and prognostic marker for prostate cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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