Thermo Fisher Scientific NOLA1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

-

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Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:1,000

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

GST Pull Down (GPD)

-

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Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human NOLA1. Recombinant protein control fragment (Product #RP-101734). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:NOLA1,uniProtId:Q9NY12-1,ncbiNodeId:9606,antigenRange:54-90,antigenLength:217,antigenImageFileName:PA5-63656_NOLA1_Q9NY12-1_Rabbit.svg,antigenImageFileNamePDP:PA5-63656_NOLA1_Q9NY12-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2644736

Product Specific Information

Immunogen sequence: GRGGFNKGQD QGPPERVVLL GEFLHPCEDD IVCKCTT

Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 95%.

Target Information

Required for ribosome biogenesis and telomere maintenance. NOLA1 is part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (psi) residues, which may serve to stabilize the conformation of rRNAs. NOLA1 may also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.