Thermo Fisher Scientific DMRT2 (Transcription Factor) Monoclonal Antibody (PCRP-DMRT2-1B11)
DMRT2 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, 인간 시료에 반응합니다. Western blot, Flow cytometry 등 다양한 응용에 적합하며, 핵 내 DMRT2 단백질 검출에 유용합니다. 24개월 안정성 보유, Protein A/G 정제, 액상 형태로 제공됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
| Peptide Array (Array) | Assay-dependent |
| Immunoelectrophoresis (IE) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PCRP-DMRT2-1B11 |
| Immunogen | Recombinant full-length human DMRT2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Antibody is stable for 24 months.
- Positive Control: HeLa or MCF-7 cells
- Cellular Localization: Nucleus
Specificity Comments:
The DMRT2 gene belongs to the DMRT gene family, sharing a DM DNA-binding domain with Drosophila (dsx) and C. elegans mab3, genes involved in sex determination. This gene is located on chromosome 9p24.3, a region associated with gonadal dysgenesis and XY sex reversal. It functions as a transcriptional activator regulating early activation of MYF5 by binding sequence-specifically to its early epaxial enhancer. DMRT2 is involved in somitogenesis and somite development, contributing to differentiation into sclerotome and dermomyotome, and is required for proper organization of these tissues.
Target Information
Gonadal dysgenesis in 9p-deleted individuals might result from combined hemizygosity of DMRT1 and DMRT2.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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