Thermo Fisher Scientific Human PEN2 Synthetic Peptide
인간 PEN2 단백질의 C-말단 13개 아미노산 서열 기반 합성 펩타이드. 항체 PA5-20301의 블로킹 펩타이드로 사용 가능. 감마-세크리타제 복합체 연구 및 알츠하이머 관련 단백질 연구에 활용. 연구용으로만 사용.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 13 amino acids near the carboxy terminus of human PEN2.
PEP-0426 can be used as a blocking peptide with polyclonal antibody PA5-20301.
Target Information
Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer’s disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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