Thermo Fisher Scientific RIP1 Monoclonal Antibody (C4)
RIP1 단백질을 인식하는 Mouse monoclonal antibody (Clone C4). Western blot 및 IHC(Paraffin) 실험에 적합. Human 및 Pig 시료 반응성. Protein A/G 정제, PBS + 50% glycerol 저장. 연구용 전용.
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Applications
Western Blot (WB)
- Tested Dilution: 0.01–3 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 5–30 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Pig |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | C4 |
| Immunogen | Recombinant Human RIPK1 protein, Phe17–Tyr289 (Accession #Q13546) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.05% Proclin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3090579 |
Target Information
Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptor ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at Ser-728 in a TNF-alpha-dependent manner, activating the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via Lys-63-linked chains enhances downstream communication in MAPK and NF-kappa-B pathways, leading to inflammatory gene activation. Polyubiquitinated protein binds to IKBKG/NEMO, enabling NF-kappa-B activation. RIPK1 and RIPK3 association forms a necrosis-inducing complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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