Thermo Fisher Scientific SIRP alpha Polyclonal Antibody
Rat SIRP alpha/CD172a 인식하는 Rabbit Polyclonal Antibody로서 WB, IHC, ELISA에 적합. 보존제가 없는 액상 형태이며, Protein A 및 항원 친화 크로마토그래피로 정제됨. 세포 신호 조절 연구 및 면역학 연구용에 이상적.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:2,500–1:10,000 |
| ELISA | 1:5,000–1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Rat SIRP alpha/CD172a protein (Met1–Asn373) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2788812 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Rat SIRP alpha/CD172a.
Target Information
SIRP alpha (CD172a, signal-regulatory protein alpha) is a receptor-type transmembrane glycoprotein expressed on myeloid-origin cells, including granulocytes, dendritic cells, macrophages, mast cells, and hematopoietic stem cells.
It acts as a substrate for activated tyrosine kinases such as EGFR, PDGFR, src, and insulin receptor, negatively regulating receptor tyrosine kinase-coupled signaling pathways.
Binding of SIRP alpha to CD47 results in phosphorylation of ITIMs within its cytoplasmic region, recruiting and activating tyrosine phosphatases SHP-1 and SHP-2.
This interaction plays roles in inhibition of macrophage phagocytosis, T cell and dendritic cell activation, and regulation of cellular responses to growth factors, hormones, and oncogenes.
Cancer cells highly express CD47, activating SIRP alpha and inhibiting macrophage-mediated destruction of tumor cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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