Thermo Fisher Scientific CWC22 Polyclonal Antibody
CWC22 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal antibody로, WB와 ELISA에 적합합니다. 고순도 친화 크로마토그래피 정제, 액상 형태, -20°C 보관. pre-mRNA 스플라이싱 및 EJC 조립 연구용에 적합.
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Thermo Fisher Scientific CWC22 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 639–908 of human CWC22 (NP_065994.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.04 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805283 |
Product Specific Information
- Immunogen sequence: LTDELREHLK NTPKVIVAQK PDVEQNKSSP SSSSSASSSS ESDSSDSDSD SSDSSSESSS EESDSSSISS HSSASANDVR KKGHGKTRSK EVDKLIRNQQ TNDRKQKERR QEHGHQETRT ERERRSEKHR DQNSSGSNWR DPITKYTSDK DVPSERNNYS RVANDRDQEM HIDLENKHGD PKKKRGERRN SFSENEKHTH RIKDSENFRR KDRSKSKEMN RKHSGSRSDE DRYQNGAERR WEKSSRYSEQ SRESKKNQDR RREKSPAKQK
- Positive Samples: Mouse liver, Mouse testis
- Cellular Location: Nucleus, Nucleus speckle
Target Information
Required for pre-mRNA splicing as a component of the spliceosome (PubMed:12226669, PubMed:11991638, PubMed:22961380, PubMed:28502770, PubMed:28076346, PubMed:29360106, PubMed:29301961).
Promotes exon-junction complex (EJC) assembly (PubMed:22959432, PubMed:22961380).
Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs.
Through its role in EJC assembly, required for nonsense-mediated mRNA decay. [UniProt]
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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