Thermo Fisher Scientific CWC22 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 639-908 of human CWC22 (NP_0659941) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CWC22,uniProtId:Q9HCG8-1,ncbiNodeId:9606,antigenRange:639-908,antigenLength:908,antigenImageFileName:PA5-88996_CWC22_Q9HCG8-1_Rabbit.svg,antigenImageFileNamePDP:PA5-88996_CWC22_Q9HCG8-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.04 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2805283

Product Specific Information

Immunogen sequence: LTDELREHLK NTPKVIVAQK PDVEQNKSSP SSSSSASSSS ESDSSDSDSD SSDSSSESSS EESDSSSISS HSSASANDVR KKGHGKTRSK EVDKLIRNQQ TNDRKQKERR QEHGHQETRT ERERRSEKHR DQNSSGSNWR DPITKYTSDK DVPSERNNYS RVANDRDQEM HIDLENKHGD PKKKRGERRN SFSENEKHTH RIKDSENFRR KDRSKSKEMN RKHSGSRSDE DRYQNGAERR WEKSSRYSEQ SRESKKNQDR RREKSPAKQK; Positive Samples: Mouse liver, Mouse testis; Cellular Location: Nucleus, Nucleus speckle

Target Information

Required for pre-mRNA splicing as component of the spliceosome (PubMed:12226669, PubMed:11991638, PubMed:22961380, PubMed:28502770, PubMed:28076346, PubMed:29360106, PubMed:29301961). Promotes exon-junction complex (EJC) assembly (PubMed:22959432, PubMed:22961380). Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. [UniProt]

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.