Thermo Fisher Scientific CD3e (T-Cell Marker) Monoclonal Antibody (C3e/2478)

Applications

Product Specifications

Target Information

The CD3 subunit complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and regulating the cell surface expression of the TCR complex.
T cell activation through the TCR involves the CD3 subunits (gamma, delta, epsilon, zeta), which are structurally related members of the immunoglobulin superfamily encoded by closely linked genes on human chromosome 11.

CD3 components have long cytoplasmic tails that associate with signal transduction molecules via a double tyrosine-based motif. CD3 may play roles in TCR-induced growth arrest, cell survival, and proliferation.

CD3 antigen is present on:

• 68–82% of normal peripheral blood lymphocytes
• 65–85% of thymocytes
• Purkinje cells in the cerebellum

It is not expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in certain autoimmune diseases.
Genes encoding CD3 epsilon, gamma, and delta are located on chromosome 11.
Defects in the CD3 gene are associated with CD3 immunodeficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.