Thermo Fisher Scientific CD3e (T-Cell Marker) Monoclonal Antibody (C3e/2478)
CD3e 단백질을 표적하는 Mouse IgG1 단클론 항체로, 인간 시료에 반응합니다. Western Blot, Flow Cytometry, ELISA, Peptide Array 등 다양한 응용에 적합하며, T세포 표지자 연구에 유용합니다. PBS 기반 액상 형태로 4°C에서 보관합니다.
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- 916-MSM14-Px (2개 옵션)
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카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD3e (T-Cell Marker) Monoclonal Antibody (C3e/2478)
Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
| ELISA | 2–4 µg/mL |
| Peptide Array | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | C3e/2478 |
| Immunogen | Recombinant human CD3e fragment (around aa 23–119) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The CD3 subunit complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and regulating the cell surface expression of the TCR complex.
T cell activation through the TCR involves the CD3 subunits (gamma, delta, epsilon, zeta), which are structurally related members of the immunoglobulin superfamily encoded by closely linked genes on human chromosome 11.
CD3 components have long cytoplasmic tails that associate with signal transduction molecules via a double tyrosine-based motif. CD3 may play roles in TCR-induced growth arrest, cell survival, and proliferation.
CD3 antigen is present on:
- 68–82% of normal peripheral blood lymphocytes
- 65–85% of thymocytes
- Purkinje cells in the cerebellum
It is not expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in certain autoimmune diseases.
Genes encoding CD3 epsilon, gamma, and delta are located on chromosome 11.
Defects in the CD3 gene are associated with CD3 immunodeficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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