Thermo Fisher Scientific LDLR Polyclonal Antibody
LDLR 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 적합합니다. 인간, 마우스, 랫트 반응성을 가지며, 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human LDLR (Accession P01130), corresponding to amino acid residues G516–I566 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900140 |
Product Specific Information
Antibody detects endogenous levels of total LDLR.
Target Information
The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell, ending up in lysosomes where the protein is degraded and cholesterol becomes available for repression of microsomal enzyme HMG CoA reductase, the rate-limiting step in cholesterol synthesis. Mutations in the LDL-R gene cause familial hypercholesterolemia. LDL-R also acts as an entry factor for Hepatitis C virus along with SCARB1, CLDN1, and CD81. At least three isoforms of LDL-R are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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