Thermo Fisher Scientific LDLR Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total LDLR.

Target Information

The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell, ending up in lysosomes where the protein is degraded and cholesterol becomes available for repression of microsomal enzyme HMG CoA reductase, the rate-limiting step in cholesterol synthesis. Mutations in the LDL-R gene cause familial hypercholesterolemia. LDL-R also acts as an entry factor for Hepatitis C virus along with SCARB1, CLDN1, and CD81. At least three isoforms of LDL-R are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.